Welcome to the Skokowa-Welte Lab

Main focus of our laboratory is a better understanding of the biological and pathological processes operating during development, differentiation and leukemogenic transformation of hematopoietic stem cells. We study human, mouse and fish (zebrafish and medaka) blood cell development in physiological conditions and disease (inherited bone marrow failure syndromes and leukemia). Our goals are to delineate central laws of the hematopoietic stem cell specification and malignant transformation using multidisciplinary approaches covering different research fields. We are using this knowledge to establish novel therapies for patients with inherited bone marrow syndromes and malignant blood diseases.

Our main research topics are:

– Pathophysiology of pre-leukemia bone marrow failure syndromes, severe congenital neutropenia (CN, Kostmann syndrome)
– Mechanisms of G-CSF-triggered myeloid differentiation of HSPCs
– Disease modeling using patients-derived iPSCs
– CRISPR/Cas9-mediated gene editing in HSPCs and iPSCs
– Processes operating during blood cell development and leukemogenic transformation in zebrafish and medaka
– Modeling of congenital neutropenia and leukemia in mouse and fish
– The role NAMPT-mediated protein deacetylation in hematopoietic differentiation and leukemia
– Improvement of the diagnostic processes for patients with severe congenital neutropenia (search for new gene mutations, deep-seq of acquired CSF3R, and RUNX1 mutations)