Publications

Selected publications

2022

Yang, M., Pan, Z., Huang, K., Busche, G., Liu, H., Gohring, G., Rumpel, R., Dittrich-Breiholz, O., Talbot, S., Scherr, M., Chaturvedi, A., Eder, M., Skokowa, J., Zhou, J., Welte, K., von Neuhoff, N., Liu, L., Ganser, A. & Li, Z. A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation. Leukemia 36, 675-686 (2022).

Skokowa, J., Hernandez Alvarez, B., Coles, M., Ritter, M., Nasri, M., Haaf, J., Aghaallaei, N., Xu, Y., Mir, P., Krahl, A.C., Rogers, K.W., Maksymenko, K., Bajoghli, B., Welte, K., Lupas, A.N., Muller, P. & ElGamacy, M. A topological refactoring design strategy yields highly stable granulopoietic proteins. Nat Commun 13, 2948 (2022).

Nikolouzakis, T.K., Spyridakis, K., Tzardi, M., Tsaknakis, G., Ximeri, M., Klimiankou, M., Chrysos, E., Skokowa, J. & Papadaki, H.A. Chronic neutropenic colitis with complete colonic obstruction in a patient with severe congenital neutropenia associated with G6PC3 mutations. Ann Hematol 101, 1583-1585 (2022).

Lengerke, C. & Skokowa, J. CLPB in neutropenia: 1 gene with many faces. Blood 139, 649-650 (2022).

 

Hasel de Carvalho, E., Bartok, E., Stolting, H., Bajoghli, B. & Leptin, M. Revisiting the origin of interleukin 1 in anamniotes and sub-functionalization of interleukin 1 in amniotes. Open Biol 12, 220049 (2022).

Dannenmann, B. & Skokowa, J. Generation, expansion, and drug treatment of hematopoietic progenitor cells derived from human iPSCs. STAR Protoc 3, 101400 (2022).

 

Boutakoglou, E., Klimiankou, M., Tsaknakis, G., Drakos, E., Skokowa, J. & Papadaki, H.A. Identification of GFI1 mutations in adult patients with congenital neutropenia. Ann Hematol (2022).

Borbaran-Bravo, N., Arreba-Tutusaus, P., Ritter, M.U., Nasri, M., Klimiankou, M. & Skokowa, J. Regenerative medicine meets translational oncology: Modeling leukemic bone marrow niche. Cell Rep Med 3, 100724 (2022).

Bhatia, S., Spanier, L., Bickel, D., Dienstbier, N., Woloschin, V., Vogt, M., Pols, H., Lungerich, B., Reiners, J., Aghaallaei, N., Diedrich, D., Frieg, B., Schliehe-Diecks, J., Bopp, B., Lang, F., Gopalswamy, M., Loschwitz, J., Bajohgli, B., Skokowa, J., Borkhardt, A., Hauer, J., Hansen, F.K., Smits, S.H.J., Jose, J., Gohlke, H. & Kurz, T. Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization. ACS Cent Sci 8, 636-655 (2022).

Aghaallaei, N., Inoue, D., Hasel de Carvalho, E., Dick, A.M., Wittbrodt, J., Leptin, M. & Bajoghli, B. Notch1 deficiency alters the migratory behavior of developing T cells and calcium signaling in the thymus of medaka. Eur J Immunol 52, 261-269 (2022).

Aghaallaei, N., Agarwal, R., Benjaminsen, J., Lust, K., Bajoghli, B., Wittbrodt, J. & Feijoo, C.G. Antigen-Presenting Cells and T Cells Interact in a Specific Area of the Intestinal Mucosa Defined by the Ccl25-Ccr9 Axis in Medaka. Front Immunol 13, 812899 (2022).

2021

Xu, Y., Nasri, M., Dannenmann, B., Mir, P., Zahabi, A., Welte, K., Morishima, T. & Skokowa, J. NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells. Stem Cell Res Ther 12, 112 (2021).

Witte, A., Rohlfing, A.K., Dannenmann, B., Dicenta, V., Nasri, M., Kolb, K., Sudmann, J., Castor, T., Rath, D., Borst, O., Skokowa, J. & Gawaz, M. The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4. Cardiovasc Res 117, 903-917 (2021).

Skokowa, J. Circumventing Mutation to Nix Neutropenia. N Engl J Med 384, 1956-1958 (2021).

Schurch, C., Schaefer, T., Muller, J.S., Hanns, P., Arnone, M., Dumlin, A., Scharer, J., Sinning, I., Wild, K., Skokowa, J., Welte, K., Carapito, R., Bahram, S., Konantz, M. & Lengerke, C. SRP54 mutations induce congenital neutropenia via dominant-negative effects on XBP1 splicing. Blood 137, 1340-1352 (2021).

Klimiankou, M. & Skokowa, J. Old drug revisited: disulfiram, NETs, and sepsis. Blood 138, 2604-2605 (2021).

Doll, L., Aghaallaei, N., Dick, A.M., Welte, K., Skokowa, J. & Bajoghli, B. A zebrafish model for HAX1-associated congenital neutropenia. Haematologica 106, 1311-1320 (2021).

Deordieva, E., Shvets, O., Voronin, K., Maschan, A., Welte, K., Skokowa, J., Novichkova, G. & Shcherbina, A. Nicotinamide (vitamin B3) treatment improves response to G-CSF in severe congenital neutropenia patients. Br J Haematol 192, 788-792 (2021).

Dannenmann, B., Klimiankou, M., Oswald, B., Solovyeva, A., Mardan, J., Nasri, M., Ritter, M., Zahabi, A., Arreba-Tutusaus, P., Mir, P., Stein, F., Kandabarau, S., Lachmann, N., Moritz, T., Morishima, T., Konantz, M., Lengerke, C., Ripperger, T., Steinemann, D., Erlacher, M., Niemeyer, C.M., Zeidler, C., Welte, K. & Skokowa, J. iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia. Cell Stem Cell 28, 906-922.e906 (2021).

Aghaallaei, N., Dick, A.M., Tsingos, E., Inoue, D., Hasel, E., Thumberger, T., Toyoda, A., Leptin, M., Wittbrodt, J. & Bajoghli, B. alphabeta/gammadelta T cell lineage outcome is regulated by intrathymic cell localization and environmental signals. Sci Adv 7(2021).

2020

Witte, A., Rohlfing, A.K., Dannenmann, B., Dicenta, V., Nasri, M., Kolb, K., Sudmann, J., Castor, T., Rath, D., Borst, O., Skokowa, J. & Gawaz, M. The chemokine CXCL14 mediates platelet function and migration via direct interaction with CXCR4. Cardiovasc Res (2020).

Ritter, M., Klimiankou, M., Klimenkova, O., Schambach, A., Hoffmann, D., Schmidt, A., Kanz, L., Link, D.C., Welte, K. & Skokowa, J. Cooperating, congenital neutropenia-associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs. Ann Hematol 99, 2329-2338 (2020).

Papadaki, H.A., Mavroudi, I., Almeida, A., Bux, J., Cichy, J., Dale, D.C., Donadieu, J., Höglund, P., Karanfilski, O., Mecucci, C., Palmblad, J., Skokowa, J., Stamatopoulos, K., Touw, I., Warren, A.J., Welte, K., Zeidler, C. & Dufour, C. Congenital and Acquired Chronic Neutropenias: Challenges, Perspectives and Implementation of the EuNet-INNOCHRON Action. Hemasphere 4, e406 (2020).

Nasri, M., Ritter, M., Mir, P., Dannenmann, B., Aghaallaei, N., Amend, D., … & Steiert, I. (2020). CRISPR/Cas9-mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients. Haematologica, 105(3), 598-609.

Mir, P., Ritter, M., Welte, K., Skokowa, J. & Klimiankou, M. Gene Knockout in Hematopoietic Stem and Progenitor Cells Followed by Granulocytic Differentiation. Methods Mol Biol 2115, 455-469 (2020).

Mir, P., Klimiankou, M., Findik, B., Hähnel, K., Mellor-Heineke, S., Zeidler, C., Skokowa, J. & Welte, K. New insights into the pathomechanism of cyclic neutropenia. Ann N Y Acad Sci 1466, 83-92 (2020).

Hoffmann, D., Kuehle, J., Lenz, D., Philipp, F., Zychlinski, D., Lachmann, N., Moritz, T., Steinemann, D., Morgan, M., Skokowa, J., Klein, C. & Schambach, A. Lentiviral gene therapy and vitamin B3 treatment enable granulocytic differentiation of G6PC3-deficient induced pluripotent stem cells. Gene Ther 27, 297-306 (2020).

Hernandez Alvarez, B., Skokowa, J., Coles, M., Mir, P., Nasri, M., Maksymenko, K., Weidmann, L., Rogers, K.W., Welte, K., Lupas, A.N., Müller, P. & ElGamacy, M. Design of novel granulopoietic proteins by topological rescaffolding. PLoS Biol 18, e3000919 (2020).

Doll, L., Aghaallaei, N., Dick, A. M., Welte, K., Skokowa, J., & Bajoghli, B. (2020). A zebrafish model for HAX1-associated congenital neutropenia. Haematologica.

Dannenmann, B., Nasri, M., Welte, K. & Skokowa, J. CRISPR/Cas9 Genome Editing of Human-Induced Pluripotent Stem Cells Followed by Granulocytic Differentiation. Methods Mol Biol 2115, 471-483 (2020).

2019

Pylaeva, E., Harati, M.D., Spyra, I., Bordbari, S., Strachan, S., Thakur, B.K., Höing, B., Franklin, C., Skokowa, J., Welte, K., Schadendorf, D., Bankfalvi, A., Brandau, S., Lang, S. & Jablonska, J. NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophils. Int J Cancer 144, 136-149 (2019).

Nasri, M., Mir, P., Dannenmann, B., Amend, D., Skroblyn, T., Xu, Y., Schulze-Osthoff, K., Klimiankou, M., Welte, K. & Skokowa, J. Fluorescent labeling of CRISPR/Cas9 RNP for gene knockout in HSPCs and iPSCs reveals an essential role for GADD45b in stress response. Blood Adv 3, 63-71 (2019).

Morishima, T., Krahl, A.C., Nasri, M., Xu, Y., Aghaallaei, N., Findik, B., Klimiankou, M., Ritter, M., Hartmann, M.D., Gloeckner, C.J., Stefanczyk, S., Lindner, C., Oswald, B., Bernhard, R., Hahnel, K., Hermanutz-Klein, U., Ebinger, M., Handgretinger, R., Casadei, N., Welte, K., Andre, M., Muller, P., Bajoghli, B. & Skokowa, J. LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. Blood 134, 1159-1175 (2019).

Klimiankou, M., Uenalan, M., Kandabarau, S., Nustede, R., Steiert, I., Mellor-Heineke, S., Zeidler, C., Skokowa, J. & Welte, K. Ultra-Sensitive CSF3R Deep Sequencing in Patients With Severe Congenital Neutropenia. Front Immunol10, 116 (2019).

Jung, J., Buisman, S.C., Weersing, E., Dethmers-Ausema, A., Zwart, E., Schepers, H., Dekker, M.R., Lazare, S.S., Hammerl, F., Skokova, Y., Kooistra, S.M., Klauke, K., Poot, R.A., Bystrykh, L.V. & de Haan, G. CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions. Cell Rep 26, 1906-1918.e1908 (2019).

Dannenmann, B., Zahabi, A., Mir, P., Oswald, B., Bernhard, R., Klimiankou, M., Morishima, T., Schulze-Osthoff, K., Zeidler, C., Kanz, L., Lachmann, N., Moritz, T., Welte, K. & Skokowa, J. Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34(+) cells preceding leukemic transformation. Exp Hematol 71, 51-60 (2019).

Bajoghli, B., Dick, A.M., Claasen, A., Doll, L. & Aghaallaei, N. Zebrafish and Medaka: Two Teleost Models of T-Cell and Thymic Development. Int J Mol Sci 20(2019).

2018

Skokowa, J., Zeidler, C. & Welte, K. Chronische Neutropenien im Kindesalter. Monatsschrift Kinderheilkunde 166, 977-986 (2018).

Aghaallaei, N. & Bajoghli, B. Making Thymus Visible: Understanding T-Cell Development from a New Perspective. Front Immunol 9, 375 (2018).

2017

Skokowa, J., Dale, D. C., Touw, I. P., Zeidler, C., & Welte, K. (2017). Severe congenital neutropenias. Nature Reviews Disease Primers, 3(1), 1-18.

Koch, C., Samareh, B., Morishima, T., Mir, P., Kanz, L., Zeidler, C., Skokowa, J. & Welte, K. GM-CSF treatment is not effective in congenital neutropenia patients due to its inability to activate NAMPT signaling. Ann Hematol 96, 345-353 (2017).

2016

Wolf, B., Krieg, K., Falk, C., Breuhahn, K., Keppeler, H., Biedermann, T., Schmid, E., Warmann, S., Fuchs, J., Vetter, S., Thiele, D., Nieser, M., Avci-Adali, M., Skokowa, Y., Schöls, L., Hauser, S., Ringelhan, M., Yevsa, T., Heikenwalder, M. & Kossatz-Boehlert, U. Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma. Cancer Res 76, 5550-5561 (2016).

Pramono, A., Zahabi, A., Morishima, T., Lan, D., Welte, K. & Skokowa, J. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1alpha-dependent activation of a BMP4 autoregulatory loop. Ann N Y Acad Sci 1375, 38-51 (2016).

Nustede, R., Klimiankou, M., Klimenkova, O., Kuznetsova, I., Zeidler, C., Welte, K. & Skokowa, J. ELANE mutant-specific activation of different UPR pathways in congenital neutropenia. Br J Haematol 172, 219-227 (2016).

Klimiankou, M., Mellor-Heineke, S., Zeidler, C., Welte, K. & Skokowa, J. Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia. Ann N Y Acad Sci 1370, 119-125 (2016).

Klimiankou, M., Mellor-Heineke, S., Klimenkova, O., Reinel, E., Uenalan, M., Kandabarau, S., Skokowa, J., Welte, K. & Zeidler, C. Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML. Blood 127, 2638-2641 (2016).

2015

Zhang, H., Goudeva, L., Immenschuh, S., Schambach, A., Skokowa, J., Eiz-Vesper, B., Blasczyk, R. & Figueiredo, C. miR-155 is associated with the leukemogenic potential of the class IV granulocyte colony-stimulating factor receptor in CD34⁺ progenitor cells. Mol Med 20, 736-746 (2015).

Makaryan, V., Zeidler, C., Bolyard, A.A., Skokowa, J., Rodger, E., Kelley, M.L., Boxer, L.A., Bonilla, M.A., Newburger, P.E., Shimamura, A., Zhu, B., Rosenberg, P.S., Link, D.C., Welte, K. & Dale, D.C. The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. Curr Opin Hematol 22, 3-11 (2015).

Lachmann, N., Ackermann, M., Frenzel, E., Liebhaber, S., Brennig, S., Happle, C., Hoffmann, D., Klimenkova, O., Lüttge, D., Buchegger, T., Kühnel, M.P., Schambach, A., Janciauskiene, S., Figueiredo, C., Hansen, G., Skokowa, J. & Moritz, T. Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. Stem Cell Reports 4, 282-296 (2015).

Kruger, P., Saffarzadeh, M., Weber, A.N., Rieber, N., Radsak, M., von Bernuth, H., Benarafa, C., Roos, D., Skokowa, J. & Hartl, D. Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS Pathog 11, e1004651 (2015).

Klimiankou, M., Klimenkova, O., Uenalan, M., Zeidler, A., Mellor-Heineke, S., Kandabarau, S., Skokowa, J., Zeidler, C. & Welte, K. GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations. Blood 126, 1865-1867 (2015).

2014

Skokowa, J., Steinemann, D., Katsman-Kuipers, J.E., Zeidler, C., Klimenkova, O., Klimiankou, M., Unalan, M., Kandabarau, S., Makaryan, V., Beekman, R., Behrens, K., Stocking, C., Obenauer, J., Schnittger, S., Kohlmann, A., Valkhof, M.G., Hoogenboezem, R., Gohring, G., Reinhardt, D., Schlegelberger, B., Stanulla, M., Vandenberghe, P., Donadieu, J., Zwaan, C.M., Touw, I.P., van den Heuvel-Eibrink, M.M., Dale, D.C. & Welte, K. Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis. Blood 123, 2229-2237 (2014).

Makaryan, V., Rosenthal, E.A., Bolyard, A.A., Kelley, M.L., Below, J.E., Bamshad, M.J., Bofferding, K.M., Smith, J.D., Buckingham, K., Boxer, L.A., Skokowa, J., Welte, K., Nickerson, D.A., Jarvik, G.P., Dale, D.C. & Genomics, U.W.C.f.M. TCIRG1-associated congenital neutropenia. Hum Mutat 35, 824-827 (2014).

Klimenkova, O., Ellerbeck, W., Klimiankou, M., Unalan, M., Kandabarau, S., Gigina, A., Hussein, K., Zeidler, C., Welte, K. & Skokowa, J. A lack of secretory leukocyte protease inhibitor (SLPI) causes defects in granulocytic differentiation. Blood 123, 1239-1249 (2014).

Hennig, C., Ilginus, C., Boztug, K., Skokowa, J., Marodi, L., Szaflarska, A., Sass, M., Pignata, C., Kilic, S.S., Caragol, I., Baumann, U., Klein, C., Welte, K. & Hansen, G. High-content cytometry and transcriptomic biomarker profiling of human B-cell activation. J Allergy Clin Immunol 133, 172-180 e171-110 (2014).

Gupta, K., Kuznetsova, I., Klimenkova, O., Klimiankou, M., Meyer, J., Moore, M.A., Zeidler, C., Welte, K. & Skokowa, J. Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34(+) cells. Blood 123, 2550-2561 (2014).

2013

Skokowa, J. & Welte, K. Defective G-CSFR signaling pathways in congenital neutropenia. Hematol Oncol Clin North Am 27, 75-88, viii (2013).

2012

Zeidler, L., Zimmermann, M., Moricke, A., Meissner, B., Bartels, D., Tschan, C., Schrauder, A., Cario, G., Goudeva, L., Jager, S., Ratei, R., Ludwig, W.D., Teigler-Schlegel, A., Skokowa, J., Koehler, R., Bartram, C.R., Riehm, H., Schrappe, M., Welte, K. & Stanulla, M. Low platelet counts after induction therapy for childhood acute lymphoblastic leukemia are strongly associated with poor early response to treatment as measured by minimal residual disease and are prognostic for treatment outcome. Haematologica 97, 402-409 (2012).

Thakur, B.K., Lippka, Y., Dittrich, T., Chandra, P., Skokowa, J. & Welte, K. NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression. Biochem Biophys Res Commun 420, 714-720 (2012).

Skokowa, J., Klimiankou, M., Klimenkova, O., Lan, D., Gupta, K., Hussein, K., Carrizosa, E., Kusnetsova, I., Li, Z., Sustmann, C., Ganser, A., Zeidler, C., Kreipe, H.H., Burkhardt, J., Grosschedl, R. & Welte, K. Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med 18, 1550-1559 (2012).

Dan, L., Klimenkova, O., Klimiankou, M., Klusman, J.H., van den Heuvel-Eibrink, M.M., Reinhardt, D., Welte, K. & Skokowa, J. The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells. Haematologica 97, 551-559 (2012).

2010-2001

Skokowa, J. & Welte, K. Dysregulation of myeloid-specific transcription factors in congenital neutropenia. Ann N Y Acad Sci 1176, 94-100 (2009).

Skokowa, J., Lan, D., Thakur, B.K., Wang, F., Gupta, K., Cario, G., Brechlin, A.M., Schambach, A., Hinrichsen, L., Meyer, G., Gaestel, M., Stanulla, M., Tong, Q. & Welte, K. NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med 15, 151-158 (2009).

Skokowa, J., Fobiwe, J.P., Dan, L., Thakur, B.K. & Welte, K. Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1. Blood 114, 3044-3051 (2009).

Germeshausen, M., Skokowa, J., Ballmaier, M., Zeidler, C. & Welte, K. G-CSF receptor mutations in patients with congenital neutropenia. Curr Opin Hematol 15, 332-337 (2008).

Skokowa, J. & Welte, K. LEF-1 is a decisive transcription factor in neutrophil granulopoiesis. Ann N Y Acad Sci 1106, 143-151 (2007).

Skokowa, J., Germeshausen, M., Zeidler, C. & Welte, K. Severe congenital neutropenia: inheritance and pathophysiology. Curr Opin Hematol 14, 22-28 (2007).

Cario, G., Izraeli, S., Teichert, A., Rhein, P., Skokowa, J., Moricke, A., Zimmermann, M., Schrauder, A., Karawajew, L., Ludwig, W.D., Welte, K., Schunemann, H.J., Schlegelberger, B., Schrappe, M. & Stanulla, M. High interleukin-15 expression characterizes childhood acute lymphoblastic leukemia with involvement of the CNS. J Clin Oncol 25, 4813-4820 (2007).

Skokowa, J., Cario, G., Uenalan, M., Schambach, A., Germeshausen, M., Battmer, K., Zeidler, C., Lehmann, U., Eder, M., Baum, C., Grosschedl, R., Stanulla, M., Scherr, M. & Welte, K. LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat Med 12, 1191-1197 (2006).

Leonhardt, J., Stanulla, M., von Wasielewski, R., Skokowa, J., Kubler, J., Ure, B.M. & Petersen, C. Gene expression profile of the infective murine model for biliary atresia. Pediatr Surg Int 22, 84-89 (2006).

Wang, Z., Skokowa, J., Pramono, A., Ballmaier, M. & Welte, K. Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cells. Ann N Y Acad Sci 1044, 29-40 (2005).

Skokowa, J., Ali, S.R., Felda, O., Kumar, V., Konrad, S., Shushakova, N., Schmidt, R.E., Piekorz, R.P., Nurnberg, B., Spicher, K., Birnbaumer, L., Zwirner, J., Claassens, J.W., Verbeek, J.S., van Rooijen, N., Kohl, J. & Gessner, J.E. Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol 174, 3041-3050 (2005).

Cario, G., Skokowa, J., Wang, Z., Bucan, V., Zeidler, C., Stanulla, M., Schrappe, M. & Welte, K. Heterogeneous expression pattern of pro- and anti-apoptotic factors in myeloid progenitor cells of patients with severe congenital neutropenia treated with granulocyte colony-stimulating factor. Br J Haematol 129, 275-278 (2005).

Shushakova, N., Skokowa, J., Schulman, J., Baumann, U., Zwirner, J., Schmidt, R.E. & Gessner, J.E. C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. J Clin Invest 110, 1823-1830 (2002).

Radeke, H.H., Janssen-Graalfs, I., Sowa, E.N., Chouchakova, N., Skokowa, J., Loscher, F., Schmidt, R.E., Heeringa, P. & Gessner, J.E. Opposite regulation of type II and III receptors for immunoglobulin G in mouse glomerular mesangial cells and in the induction of anti-glomerular basement membrane (GBM) nephritis. J Biol Chem 277, 27535-27544 (2002).

Luhrmann, A., Deiters, U., Skokowa, J., Hanke, M., Gessner, J.E., Muhlradt, P.F., Pabst, R. & Tschernig, T. In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application. Infect Immun 70, 3785-3792 (2002).

Chouchakova, N., Skokowa, J., Baumann, U., Tschernig, T., Philippens, K.M., Nieswandt, B., Schmidt, R.E. & Gessner, J.E. Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation. J Immunol 166, 5193-5200 (2001).

Funding